Lesko LJ, Zineh I, Huang SM: What Is Clinical Utility and Why Should We Care? Clin Pharmacol Ther 2010, 88(6):729-733.

…This issue of Clinical Pharmacology & Therapeutics addresses the complexities and challenges of defining and demonstrating clinical utility in the era of personalized medicine. “Utility” is a term that is ubiquitously used in fields ranging from economics to medicine. Broadly speaking, utility is a measure of the personal benefit that someone has from an intervention, outcome, product, or process. “Clinical utility” is a term that is widely used in medicine to describe the relevance and usefulness of an intervention in patient care. Despite general agreement that clinical utility assessments are multidimensional and may include economic, clinical, and/or humanistic domains, there is no consensus on its definition or how to robustly demonstrate it to the satisfaction of multiple stakeholders…

http://www.nature.com/clpt/journal/v88/n6/full/clpt2010229a.html